Breakthrough cancer-killing treatment has no side-effects in mice: New chemistry may cure human cancers

Apr. 3, 2013 ? Cancer painfully ends more than 500,000 lives in the United States each year, according to the Centers for Disease Control and Prevention. The scientific crusade against cancer recently achieved a victory under the leadership of University of Missouri Curators' Professor M. Frederick Hawthorne. Hawthorne's team has developed a new form of radiation therapy that successfully put cancer into remission in mice. This innovative treatment produced none of the harmful side-effects of conventional chemo and radiation cancer therapies.

Clinical trials in humans could begin soon after Hawthorne secures funding.

"Since the 1930s, scientists have sought success with a cancer treatment known as boron neutron capture therapy (BNCT)," said Hawthorne, a recent winner of the National Medal of Science awarded by President Obama in the White House. "Our team at MU's International Institute of Nano and Molecular Medicine finally found the way to make BNCT work by taking advantage of a cancer cell's biology with nanochemistry."

Cancer cells grow faster than normal cells and in the process absorb more materials than normal cells. Hawthorne's team took advantage of that fact by getting cancer cells to take in and store a boron chemical designed by Hawthorne. When those boron-infused cancer cells were exposed to neutrons, a subatomic particle, the boron atom shattered and selectively tore apart the cancer cells, sparing neighboring healthy cells.

The physical properties of boron made Hawthorne's technique possible. A particular form of boron will split when it captures a neutron and release lithium, helium and energy. Like pool balls careening around a billiards table, the helium and lithium atoms penetrate the cancer cell and destroy it from the inside without harming the surrounding tissues.

"A wide variety of cancers can be attacked with our BNCT technique," Hawthorne said. "The technique worked excellently in mice. We are ready to move on to trials in larger animals, then people. However, before we can start treating humans, we will need to build suitable equipment and facilities. When it is built, MU will have the first radiation therapy of this kind in the world."

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The above story is reprinted from materials provided by University of Missouri-Columbia.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. P. J. Kueffer, C. A. Maitz, A. A. Khan, S. A. Schuster, N. I. Shlyakhtina, S. S. Jalisatgi, J. D. Brockman, D. W. Nigg, M. F. Hawthorne. Boron neutron capture therapy demonstrated in mice bearing EMT6 tumors following selective delivery of boron by rationally designed liposomes. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1303437110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/j8W2J0YwEmo/130403131354.htm

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6000 died in Syria in March, deadliest month yet

In this Thursday March 28, 2013 image taken from video obtained from the Ugarit News, which has been authenticated based on its contents and other AP reporting, shows a building at the Syrian government checkpoint on fire, in Dael less than 15 kilometers (10 miles) from the Jordanian border in Daraa province, Syria. Thursday, March 28, 2013. Syrian rebels on Friday captured a strategic town near the border with Jordan after a day of fierce clashes that killed dozens of people, activists said, as opposition fighters expand their presence in the south, considered a gateway to Damascus. (AP Photo/Ugarit News via AP video)

In this Thursday March 28, 2013 image taken from video obtained from the Ugarit News, which has been authenticated based on its contents and other AP reporting, shows a building at the Syrian government checkpoint on fire, in Dael less than 15 kilometers (10 miles) from the Jordanian border in Daraa province, Syria. Thursday, March 28, 2013. Syrian rebels on Friday captured a strategic town near the border with Jordan after a day of fierce clashes that killed dozens of people, activists said, as opposition fighters expand their presence in the south, considered a gateway to Damascus. (AP Photo/Ugarit News via AP video)

In this Thursday March 28, 2013 image taken from video obtained from the Shaam News Network, which has been authenticated based on its contents and other AP reporting, shows heavy clashes between Syrian Free Army fighters and the regime?s army in Dael less than 15 kilometers (10 miles) from the Jordanian border in Daraa province, Syria. Syrian rebels on Friday captured a strategic town near the border with Jordan after a day of fierce clashes that killed dozens of people, activists said, as opposition fighters expand their presence in the south, considered a gateway to Damascus. (AP Photo/Shaam News Network via AP video)

In this Thursday March 28, 2013 image taken from video obtained from the Shaam News Network, which has been authenticated based on its contents and other AP reporting, shows Syrian Free Army fighters in Dael less than 15 kilometers (10 miles) from the Jordanian border in Daraa province, Syria. Syrian rebels on Friday captured a strategic town near the border with Jordan after a day of fierce clashes that killed at least 38 people, activists said, as opposition fighters expand their presence in the south, considered a gateway to Damascus. (AP Photo/Shaam News Network via AP video)

In this Thursday March 28, 2013 image taken from video obtained from the Ugarit News, which has been authenticated based on its contents and other AP reporting, shows fighters from the Syrian Free Army fire on a Syrian army position in Dael less than 15 kilometers (10 miles) from the Jordanian border in Daraa province, Syria. Syrian rebels on Friday captured a strategic town near the border with Jordan after a day of fierce clashes that killed dozens of people, activists said, as opposition fighters expand their presence in the south, considered a gateway to Damascus. (AP Photo/Ugarit News via AP video)

In this Thursday March 28, 2013 image taken from video obtained from the Shaam News Network, which has been authenticated based on its contents and other AP reporting, shows fighters from the Syrian Free Army preparing to fire on the regime?s army in Dael less than 15 kilometers (10 miles) from the Jordanian border in Daraa province. Syrian rebels on Friday captured a strategic town near the border with Jordan after a day of fierce clashes that killed dozens of people, activists said, as opposition fighters expand their presence in the south, considered a gateway to Damascus.(AP Photo/Shaam News Network via AP video)

BEIRUT (AP) ? More than 6,000 people were killed in the Syrian civil war in March alone, according to a leading activist group that reported it was the deadliest month yet in the 2-year-old conflict.

The head of the Syrian Observatory for Human Rights said an increase in shelling and clashes around the country led to the high toll, which is incomplete because fighters on both sides tend to underreport their dead.

"Both sides are hiding information," Rami Abdul-Rahman said by phone from Britain, where he is based. "It is very difficult to get correct info on the fighters because they don't want the information to hurt morale."

The increase also likely represents the further spread of the civil war throughout the country.

Clashes continue to rage in the northern city of Aleppo and around the capital Damascus as well as in the central city of Homs.

And in recent weeks, rebels in the southern province of Daraa along the Jordanian border have seized towns and military bases from the government with the help of an increased influx of foreign-funded weapons.

The Observatory, which opposed President Bashar Assad's regime, said the March dead included 298 children, 291 women, 1,486 rebel fighters and army defectors and 1,464 government soldiers. The rest were unidentified civilians and fighters.

The government does not provide death tolls for the civil war.

That toll solidly beat the second most deadly month, when airstrikes, clashes and shelling killed more than 5,400 people in August 2012, Abdul-Rahman said.

He said his total death toll for the conflict through the end of March is 62,554, a number he said he guessed only reflected about half of the actual dead.

He said many deaths go unreported by the government or rebel fighters and that there are tens of thousands detained in regime and rebel prisons whose fates are not known.

The United Nations said in February that 70,000 people had been killed since the start of the conflict. It has not updated its number since.

Associated Press

Source: http://hosted2.ap.org/apdefault/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-01-Syria/id-6742518c6c364ec4a8cb62f27dd6c313

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Employment: Sacking By Text Won't Pass Good-faith... | Stuff.co.nz

OPINION: Common sense suggests that text messaging should not be used for serious communications. However, it appears that our cultural obsession with texting has led to many employers and employees trying to conduct their employment relationships by text.

There have been several recent cases in the Employment Relations Authority involving employment relationships that have ended or deteriorated as a result of abrupt or ambiguous text message exchanges.

The text message would appear to offer a quick, easy and painless means of severing the employment relationship, removing the need for the employer to have face-to-face contact with the employee. It can also be used to communicate information including anything from simple instructions to unhappy news about their future employment.

You would be surprised at how often employers try to dismiss employees by text message. The authority has repeatedly made it clear to employers that dismissals by text are unlikely to be something that a fair and reasonable employer, acting in good faith, can justify.

Moreover, the compensation awards for the hurt and humiliation associated with these types of dismissals are significant and can be very damaging to small businesses that may be more likely to communicate by text message.

Last year, former immigration minister Tuariki Delamere, the director of TDA Immigration and Student Services Ltd, was required to pay $4000 compensation to an employee for dismissing him for poor performance via the "impersonal" medium of the text message.

In a case last month, a Nelson lunch outlet, The Salad Bowl, dismissed an employee by text. The employee had only worked for the business for five hours. The employer found a shortfall of $52.35 in the till at the end of the day and concluded that the employee must have taken it.

The employer sent the employee a text that night saying, "No need to come into Salad Bowl tomorrow. We'll be in touch. Thx, Randi". The following day there was a text exchange during which the employee was told "there is no job" and was accused of taking the money, which she denied. She was awarded $5000 compensation for the hurt and humiliation of being accused of theft and the traumatising effect of her dismissal.

Similarly, the authority recently dealt with the case of a dairy farm worker who was dismissed by text message when he failed to return to work after his lunch break. He had fallen asleep and eventually texted his employer later that afternoon to explain what had happened. His employer appeared at his door unannounced the next day with a dismissal letter following on from the text sent the previous day.

The authority found that the dismissal was carried out in a procedurally unjustifiable and unfair manner, awarding $500 compensation.

However, it is not just employers who need to take care with text message communications. When both the employee and employer rely heavily on text messaging to communicate their intentions during an employment relationship, there is a real risk of a breakdown in communication, despite best intentions.

In a decision involving a small Waikato concrete laying business, A1 Bobcats, an employer and employee had a heated text exchange about a job that the employer alleged the employee had "f****d up".

After three days' absence from the workplace, the employee indicated that he wanted to keep his job: "Hey shaun thankr for the muny didn't think I had work that i gues u not gana saz u wrong bot that job crank. I dindnt want to own it, i still keen towrk. Up to u."

The employer believed the employee had already resigned because of the request (also by text) for his wages to be paid out. The employee brought a personal grievance for unjustified dismissal. The authority found that the employee had been unjustifiably dismissed, but that both parties were equally at fault for the breakdown in the relationship and failing to be responsive and communicative.

The authority commented that "Mr Griffiths and Mr Dromgool relied far too much on obscure text messages, a matter that appears far too often in cases before the authority these days".

These cases demonstrate that employers and employees are well advised to have face-to-face (or at least telephone) discussions where critical matters are in play - such as whether there is still an employment relationship.

Despite its convenience and ease of use, the blunt instrument of the text message is unhelpful when employment law requires the parties to an employment relationship to be responsive and communicative. To be clear, this does not mean simply sending more texts.

The reality is that simply sending a text in an attempt to end an employment relationship is inconsistent with the obligation of good faith.

At a minimum this requires an employer to investigate allegations, discuss them with the employee, allow time for a response and consider it genuinely before taking action. Good luck fitting all of that into 160 characters.

Susan Hornsby-Geluk is a partner at Dundas Street Employment Lawyers. susan@dundasstreet.co.nz

- ? Fairfax NZ News

Source: http://www.stuff.co.nz/business/opinion-analysis/8495550/Sacking-by-text-won-t-pass-good-faith-test

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Egg hunts, air conditioning and the energy usage of renters [Friday ...

The Atlantic Cities wonders if air conditioning-dependent cities like Miami are, in fact, more sustainable than their "older, bitterly colder brethren in the north" like Minneapolis. University of Michigan research professor Michael Silvak believes this to be case ? Minneapolis is actually three-and-a-half more energy demanding than AC-loving Miami???when it comes to heating and cooling. Silvak explains: "The main story is counter-intuitive to me as well because we hear all the time about how unsustainable it is to live in the desert. This doesn?t actually argue that that's not the case. It just says look, there's another side of the coin as well, and we should pay attention to the other extreme."?

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Co.Design marvels at a clever waterproof toilet paper caddy for campers called When Nature Calls. The main components? Half of a recycled plastic 2-liter bottle, a freezer bag, reflective tape, and plenty of twine.

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Architizer singles out?nine "eggcellent" spots to partake in an Easter egg hunt including The High Line in Manhattan and Guatemala's Tikal National Park. I think most of us will have to settle with our own backyards but intriguing picks nevertheless.

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EcoBuilding Pulse is curious as to why renters use nearly a third more energy per square foot than homeowners (as evidenced by data recently released by the U.S. Energy Information Administration). The Harvard Joint Center for Housing Studies has some solid?theories.

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TreeHugger checks out the "pure salvage" building methods of Luling, Texas-based Tiny Texas Houses. Owner Brad Kittel who, most conveniently also operates an architectural salvage business, explains: "Tons of vintage materials are at our fingertips waiting to be re-harvested ? awaiting our awakening to the responsibilities we have to live with, not destroy the planet that we share. With some imagination, these salvaged quality materials and simple Human energy, anyone can have energy efficient tiny houses to live in for the rest of their lives. Sub-Zero carbon footprint houses are not only possible they are here ? our tiny houses are proof that this concept works."

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Jezebel welcomes?advice-giving clean person and author of "My Boyfriend Barfed in My Handbag" Jolie Kerr as a new weekly columnist. In her kick-off "Squalor" post, Kerr tackles removing nasty makeup stains from a twill couch and ridding a "beautiful vintage full-length crinoline/bustle/underskirt tulle-y foofy thing" of pot smoke stench.

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Curbed maps the most famous works of birthday boy Mies van der Rohe (the famed modernist architect would have turned 127 on Wednesday). Also, love this bit from the Mies Society: "In our time, where there is no limit to excess, Mies' reductionist approach is as pertinent as ever. As we reduce the distractions and focus on the essential elements of our environment and ourselves, we find they are great, intricate, and beautiful. Less?is?more."

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Source: http://www.mnn.com/your-home/at-home/blogs/egg-hunts-air-conditioning-and-the-energy-usage-of-renters-friday-news-clump

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3 killed in 75-vehicle pileup at Virginia-NC line

GALAX, Va. (AP) ? About 75 vehicles crashed Sunday along a mountainous, foggy stretch of interstate near the Virginia-North Carolina border, killing three people and injuring more than 20 others, police said.

Traffic backed up for about 8 miles in the southbound lanes of I-77 in southwest Virginia. Authorities closed the northbound lanes so that fire trucks, ambulances and police could get to the wreck.

A series of crashes began around 1:15 p.m. Sunday in the area of Fancy Gap Mountain. There was heavy fog at the time and photos of the scene after the accident showed poor visibility.

Several vehicles caught fire in the wreck, but the blaze was put out, Virginia State Police spokeswoman Corinne Geller said.

It wasn't immediately clear how bad the injuries were or how long the interstate would be closed. Tow trucks worked to clear some of the wrecked cars and trucks.

Motorists were advised to seek alternate routes.

Source: http://news.yahoo.com/3-killed-75-vehicle-pileup-virginia-nc-line-195155232.html

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Shain Gandee Fans Mourn 'Buckwild' Star Like Family

Gandee Candy fans react on MTV and Twitter and share their shock.
By Emilee Lindner

Shain Gandee on "Buckwild"
Photo: MTV

Source: http://www.mtv.com/news/articles/1704715/shain-gandee-dead-fan-reactions.jhtml

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Quora: What Is the Best April Fool's Prank Ever?

This question originally appeared on Quora.

Answer by Sneha Reddy, Dreamer

Here are some of the famous pranks in history
1. During an interview on BBC Radio 2, on the morning of 1 April 1976, the astronomer Patrick Moore announced that at 9:47 AM a once-in-a-lifetime astronomical event was going to take place. The planet Pluto would pass behind Jupiter, temporarily causing a gravitational alignment that would reduce the Earth's own gravity. Moore told his listeners that if they jumped in the air at the exact moment this planetary alignment occurred, they would experience a strange floating sensation.
The BBC received hundreds of phone calls from listeners claiming to have felt the sensation. One woman even reported she and her eleven friends had risen from their chairs and floated around the room.

2. The April 1998 issue of the New Mexicans for Science and Reason newsletter contained an article claiming that the Alabama state legislature had voted to change the value of the mathematical constant pi from 3.14159 to the 'Biblical value' of 3.0. Soon, the article made its way onto the internet, and then it rapidly spread around the world, forwarded by email. It only became apparent how far the article had spread when the Alabama legislature began receiving hundreds of calls from people protesting the legislation. The original article, which was intended as a parody of legislative attempts to circumscribe the teaching of evolution, was written by physicist Mark Boslough

3. On 1 April 1977, the British newspaper The Guardian published a special seven-page supplement devoted to San Serriffe, a small republic said to consist of several semi-colon-shaped islands located in the Indian Ocean. A series of articles affectionately described the geography and culture of this obscure nation. Its two main islands were named Upper Caisse and Lower Caisse. Its capital was Bodoni, and its leader was General Pica. The Guardian's phones rang all day as readers sought more information about the idyllic holiday spot. Only a few noticed that everything about the island was named after printer's terminology. The success of this hoax is widely credited with launching the enthusiasm for April Foolery that gripped the British tabloids in subsequent decades.

4. On 1 April 2008, the BBC announced that camera crews filming near the Antarctic for its natural history series Miracles of Evolution had captured footage of Ad?lie penguins taking to the air. It even offered a video clip of these flying penguins, which became one of the most viewed videos on the internet. Presenter Terry Jones explained that, instead of huddling together to endure the Antarctic winter, these penguins took to the air and flew thousands of miles to the rainforests of South America where they "spend the winter basking in the tropical sun." A follow up video explained how the BBC created the special effects of the flying penguins.

5.On 1 April 1975, Australia's This Day Tonight news program revealed that the country would soon be converting to "metric time." Under the new system, there would be 100 seconds to the minute, 100 minutes to the hour, and 20-hour days. Furthermore, seconds would become millidays, minutes become centidays, and hours become decidays. The report included an interview with Deputy Premier Des Corcoran who praised the new time system. The Adelaide townhall was even shown sporting a new 10-hour metric clock face. The thumbnail shows TDT Adelaide reporter Nigel Starck posing with a smaller metric clock. TDT received numerous calls from viewers who fell for the hoax. One frustrated viewer wanted to know how he could convert his newly purchased digital clock to metric time.

More questions on April Fools' Day:

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Follow Quora on Twitter: www.twitter.com/Quora

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Source: http://www.huffingtonpost.com/quora/what-is-the-best-april-fo_b_2992961.html

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